Researchers discover that stem cell senescence drives aging

Friday, April 19, 2013

Declining levels of the protein BubR1 occur when both people and animals age, and contribute to cell senescence or deterioration, weight loss, muscle wasting and cataracts. Mayo Clinic researchers have shown that adult progenitor or stem cells -- important for repair and regeneration of skeletal muscle and maintenance of healthy fat tissue -- are subject to cellular senescence, and that clearance of these cells limits age-related deterioration of these tissues. The findings appear today online in the journal Cell Reports.

BubR1 is an essential part of the mitotic checkpoint, the mechanism controlling proper cell division or mitosis. Without sufficient levels of BubR1, chromosomal imbalance will occur, leading to premature aging and cancer. Using mutant mice that expressed low levels of BubR1, the researchers found development of dysfunctional tissue with impaired cell regeneration. In analyzing the progenitor populations in skeletal muscle and fat, they found that a subset of progenitors was senescent and that the tumor suppressor p53 was acting to prevent this from happening through activation of p21.

"Earlier we discovered that senescent cells accumulate in tissues with aging and that removal of these cells delays age-related functional decline in these tissues," says Jan van Deursen, Ph.D., a Mayo Clinic molecular biologist and senior author of the study. "The key advance of the current study is that the progenitor cell populations are most sensitive for senescence, thereby interfering with the innate capacity of the tissue to counteract degeneration."

Not only do the findings contribute to knowledge on cell senescence as it relates to aging and related diseases, but understanding the mechanisms may lead to future therapies, say the researchers.

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Mayo Clinic: http://www.mayoclinic.org/news

Thanks to Mayo Clinic for this article.

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Source: http://www.labspaces.net/127816/Researchers_discover_that_stem_cell_senescence_drives_aging

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Proposal from Google and Duke Energy lets companies buy renewable power

When a company wants a green data center, it often has to build its own energy sources. Google knows that's sometimes not practical, even for a company its size. To that end, it's partnering with Duke Energy on a proposed business model that would let companies explicitly purchase renewable electricity: companies could demand eco-friendly power sources, whether or not they're the most cost-efficient. The Duke approach goes to a state commission for approval within 90 days, and it might let Google expand a Lenoir, North Carolina data center (above) with a clearer conscience and minimal costs. The real challenge may be getting other utilities to follow in Duke's footsteps -- even if there are no legal hurdles, local power providers still have to implement clean energy on a large enough scale. If they do, however, environmental responsibility may be within reach to those businesses more interested in building server farms than solar farms.

Filed under: Misc, Internet, Google

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Source: Google Official Blog

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/RKlKOtPBJlM/

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Lockdown lifted as Boston manhunt continues

[Updated at 6:12 p.m. ET]

BOSTON?Thousands of law enforcement officers finished a nearly 24-hour door-to-door manhunt for a 19-year-old suspect in Monday's Boston Marathon bombings that wounded more than 170 people and left three dead. Officials announced at 6:00 p.m. that they were unable to apprehend the suspect, despite combing through a 20-block area of the Boston suburb of Watertown and shutting down the city's entire public transportation system in an effort to prevent him from fleeing.

Gov. Deval Patrick lifted his previous "shelter in place" order for the city of Boston and many surrounding areas that the city. But Patrick urged Bostonians to continue to be "vigilant" as the "very dangerous" armed and dangerous suspect has not been apprehended.

"We cannot continue to lock down an entire city or an entire state," Massachusetts State Police Col. Timothy Alben said. He added that he believes the suspect is still in the state.

A late-night police chase and shootout left one marathon bombing suspect?26-year-old Tamerlan Tsarnaev?dead and the other, his younger brother, on the lam. One police officer was killed and another seriously wounded during the violent spree. The city of Boston and its surrounding areas ground to a standstill for hours as police went door to door searching for the suspect in the suburb of Watertown.

NBC News reported that police uncovered seven improvised explosive devices (IEDs) in Watertown and in the brothers' home in Cambridge.

The suspect on the run is Dzhokhar A. Tsarnaev, 19, of Cambridge, Mass., a student at the University of Massachusetts Dartmouth. He and his brother's family is originally from Chechnya, a volatile and once war-torn southern Russian republic. The family fled to Kyrgyzstan and eventually immigrated to the United States as refugees about 10 years ago.

Marathon bombing suspect Tsarnaev (FBI)

His older brother studied at a local community college and was a Golden Gloves boxer. Tamerlan Tsarnaev also reportedly had a wife and young child. Dzhokhar Tsarnaev, who was remembered by former classmates as bright and personable, posted links to pro-Chechnyan independence sites on his social media page, and listed his world view as "Islam." It's unclear if either the separatist politics of Chechnya or their religion had anything to do with the suspects' motivations. Tsarnaev appeared to be posting to his Twitter account even after the attacks, writing in his last post on Wednesday, "I'm a stress free kind of guy." His posts covered everything from cute photos of his cat to rap lyrics. In an interview with The New York Times, the

suspects' father said Tamerlan was unable to become a U.S. citizen because he was arrested for hitting his girlfriend, and that he traveled to Russia last year to live for six months and renew his passport.

The suspects' uncle told the local CBS News station that the pair had lived in the country since 2002. The uncle, when told that one of his nephews was killed, replied that he deserved it. ?He deserved his. He absolutely deserved his,? Ruslan Tsarni said. ?They do not deserve to live

on this earth.?

In an emotional press conference, Tsarni said his nephews had brought shame upon his family, and called them "losers." He said they were not "able to settle themselves" and were "angry at everyone who was able to." He said he did not believe they were motivated by the radical politics in Chechnya or their Muslim religion.

"Dzhokhar, If you're alive, turn yourself in and ask for forgiveness from the victims [and] the injured," he said. "He put a shame on our family. He put a shame on the entire Chechnyan ethnicity. Turn yourself in."

He added that he hadn't been in touch with the family for several years but would not say why.

"I'm ready to kneel in front of them and ask their forgiveness," Tsarni said of the victims of his nephews' crime. "I respect this country; I love this country ... this country that gives everybody chance to be treated like human being."

The Wall Street Journal, citing unnamed law enforcement sources, said that one or both of the brothers traveled back to the Caucasus region of Russia for a year or more before returning to America again.

Tsarnaev's father, reached by the AP in Russia by phone, said his son was a "true angel" and wonderful student. He later told ABC's "Good Morning America" that he wanted his son to surrender peacefully.

The University of Massachusetts at Dartmouth announced shortly after 10:30 a.m. on Friday that they were evacuating the entire campus after learning Tsarnaev is a registered student there.

Earlier, at sunrise, Gov. Patrick ordered a shutdown of all public transit and for residents in the city of Boston and on its edges to stay indoors as a massive manhunt for the second suspect was underway. The Boston Globe reported that police are focusing on a 20-block area of Watertown and fear the suspect may be wearing explosives. Amtrak has also shut down all trains between Boston and New York.

?This situation is grave and we are trying to protect the public safety,? said Massachusetts State Police Col. Timothy Alben, who ordered a lockdown of Watertown, Waltham, Belmont, Cambridge, Newton, Allston and Brighton. Brookline was later ordered to be on lockdown as well. A no-fly zone has been declared over Watertown. The city of Boston was eerily quiet during Friday's rush hour, the city's busy intersections totally abandoned.

The mayhem began at approximately 10:20 p.m. Thursday when police said the bombing suspects shot and killed an MIT campus officer, Sean Collier, 26. The terror suspects then carjacked a Mercedes-Benz SUV with the driver inside and fled, eventually letting the driver go.

(Shortly before 2 a.m. Friday, MIT issued a statement on its website saying that the suspect "in this evening's shooting is no longer on campus. It is now safe to resume normal activities. Please remain vigilant in the coming hours." MIT, Harvard, Boston University and other local colleges have canceled classes.)

The suspects were then spotted in Watertown, where federal agents swarmed in. At approximately 3:30 a.m., Massachusetts State

Slain MIT police officer Sean Collier. (Middlesex DA)

Police issued a plea on Twitter for residents of Watertown to lock their doors and not open them for anyone, as dozens of police officers, many of them off duty, searched backyards and exteriors of houses there, and a police perimeter of several blocks was established.

Worried residents were also told to turn off their cell phones out of fear that they could trigger improvised explosive devices.

The suspects exchanged dozens of rounds of gunfire with patrol officers. According to the Washington Post, they also lobbed IEDs at officers.

Tamerlan Tsarnaev was shot by police and brought to Beth Israel Medical Center. He arrived at the hospital under cardiac arrest with multiple gunshot wounds and blast-like injuries to his chest. The second suspect fled, leading to the tense manhunt that is still underway at this hour. The Boston Globe reported that he ran over his own brother when fleeing.

A transit police officer, Richard H. Donohue, was seriously wounded during the exchange of gunfire, officials said.

K9 units and SWAT teams searched homes on Spruce Street as officers with a police robot searched an SUV that the suspects had abandoned. Multiple devices were left in the road and two handguns were recovered, according to police scanners.

"We believe this to be a terrorist," said Boston Police Commissioner Ed Davis, of Tsarnaev. "We believe this to be a man who has come here to kill people. We need to get him into custody."

[Related: FBI releases photos of suspects in Boston Marathon bombings]

In a radio alert issued issued to fellow officers, the suspect was described as a "white male with dark complexion ... with thick curly hair wearing a charcoal gray hooded sweatshirt ... possibly with an assault rifle and explosives."

Police in Watertown, Newton, Brighton and Cambridge were put on high alert. "Units use caution," an officer said. "He might have an explosive object on his person."

"Suspect 2" seen in 7-Eleven surveillance footage; police in Watertown (BPD/Getty)

President Barack Obama, who attended an interfaith service for the bombing victims in Boston on Thursday, was briefed on the overnight developments, the White House said early Friday. He received an updated briefing later in the day.

Police were able to track down images of the suspects after a victim of the attacks, Jeff Bauman, came to them with a description, Bloomberg reported Thursday. Bauman's legs were torn apart by the bomb.

--Yahoo News reporter Dylan Stableford contributed to this report from Connecticut. Liz Goodwin is reporting from New York.

Source: http://news.yahoo.com/blogs/lookout/boston-mit-shooting-explosion-suspect-watertown-064355149.html

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Boston official: Video footage shows bomb suspect

BOSTON (AP) ? In what could be a major break in the Boston Marathon case, investigators are on the hunt for a man seen in a department store surveillance video dropping off a bag at the site of the bombings, a local politician said Wednesday.

Separately, a law enforcement official confirmed that authorities have found an image of a potential suspect but don't know his name.

The development ? less than 48 hours after the attack, which left three people dead and more than 170 wounded ? marked a possible turning point in a case that has investigators analyzing photos and videos frame by frame for clues to who carried out the twin bombings and why.

City Council President Stephen Murphy, who said he was briefed by Boston police, said investigators saw the image on surveillance footage they got from a department store near the finish line and matched the findings with witness descriptions of someone leaving the scene.

"I know it's very active and very fluid right now ? that they are on the chase," Murphy said. He added: "They may be on the verge of arresting someone, and that's good."

The bombs were crudely fashioned from ordinary kitchen pressure cookers packed with explosives, nails and ball bearings, investigators and others close to the case said. Investigators suspect the devices were then hidden in black duffel bags and left on the ground.

As a result, they were looking for images of someone lugging a dark, heavy bag.

One department store video "has confirmed that a suspect is seen dropping a bag near the point of the second explosion and heading off," Murphy said.

A law enforcement official who was not authorized to discuss the case publicly and spoke to The Associated Press on the condition of anonymity confirmed only that investigators had an image of a potential suspect whose name was not known to them and who had not been questioned.

Several media outlets reported that a suspect had been identified from surveillance video taken at a Lord & Taylor department store between the sites of the bomb blasts.

The turn of events came with Boston in a state of high excitement over conflicting reports of a breakthrough.

A law enforcement official briefed on the investigation told the AP around midday that a suspect was in custody. The official, who was not authorized to divulge details of the investigation and spoke on the condition of anonymity, said the suspect was expected in federal court. But the FBI and the U.S. attorney's office in Boston said no arrests had been made.

By nightfall, there was no evidence anyone was in custody. No one was taken to court. The law enforcement official, who had affirmed there was a suspect in custody even after federal officials denied it, was unable to obtain any further information or explanation.

At least 14 bombing victims, including three children, remained in critical condition. Dozens of victims have been released from hospitals, and officials at three hospitals that treated some of the most seriously injured said they expected all their remaining patients to survive. A 2-year-old boy with a head injury was improving and might go home Thursday, Boston Children's Hospital said.

On Wednesday, investigators in white jumpsuits fanned out across the streets, rooftops and awnings around the blast site in search of clues. They picked through trash cans, plastic cup sleeves and discarded sports drink dispensers.

Boston remained under a heavy security presence, and some people admitted they were nervous about moving about in public spaces.

Tyler King, a personal trainer from Attleboro who works in Boston, said four of five clients canceled on him a day earlier because they were worried about venturing into the city. He took the train in, but "I kind of kept my head on a swivel."

Kenya Nadry, a website designer, took her 5-year-old nephew to a playground.

"There's still some sense of fear, but I feel like Boston's resilient," she said. "The fine men in blue will take care of a lot of it."

Police were stationed on street corners across downtown Boston, while National Guardsmen set up tents on the Boston Common and stationed tactical vehicles.

Dr. Horacio Hojman, associate chief of trauma at Tufts Medical Center, said patients were in surprisingly good spirits when they were brought in.

"Despite what they witnessed, despite what they suffered, despite many of them having life-threatening injuries, their spirits were not broken," he said. "And I think that should probably be the message for all of us ? that this horrible act of terror will not bring us down."

President Barack Obama and his challenger in the last election, former Massachusetts Gov. Mitt Romney, planned to visit Boston on Thursday to attend a service honoring the victims.

Obama signed an emergency declaration for Massachusetts on Wednesday and ordered federal aid to supplement the local response to the bombings.

The blasts killed 8-year-old Martin Richard, of Boston, 29-year-old Krystle Campbell, of Medford, and Lu Lingzi, a Boston University graduate student from China.

___

Associated Press writers Jay Lindsay, Pat Eaton-Robb, Steve LeBlanc, Bridget Murphy and Meghan Barr in Boston; Eileen Sullivan, Julie Pace and Lara Jakes in Washington; and Marilynn Marchione in Milwaukee contributed to this report.

Source: http://news.yahoo.com/boston-official-video-footage-shows-bomb-suspect-212720844--spt.html

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Family history of Alzheimer's associated with abnormal brain pathology

Apr. 17, 2013 ? Close family members of people with Alzheimer's disease are more than twice as likely as those without a family history to develop silent buildup of brain plaques associated with Alzheimer's disease, according to researchers at Duke Medicine.

The study, published online in the journal PLOS ONE on April 17, 2013, confirms earlier findings on a known genetic variation that increases one's risk for Alzheimer's, and raises new questions about other genetic factors involved in the disease that have yet to be identified.

An estimated 25 million people worldwide have Alzheimer's disease, and the number is expected to triple by 2050. More than 95 percent of these individuals have late-onset Alzheimer's, which usually occurs after the age of 65. Research has shown that Alzheimer's begins years to decades before it is diagnosed, with changes to the brain measurable through a variety of tests.

Family history is a known risk factor and predictor of late-onset Alzheimer's disease, and studies suggest a two- to four-fold greater risk for Alzheimer's in individuals with a mother, father, brother or sister who develop the disease. These first-degree relatives share roughly 50 percent of their genes with another member of their family. Common genetic variations, including changes to the APOE gene, account for around 50 percent of the heritability of Alzheimer's, but the disease's other genetic roots are still unexplained.

"In this study, we sought to understand whether simply having a positive family history, in otherwise normal or mildly forgetful people, was enough to trigger silent buildup of Alzheimer's plaques and shrinkage of memory centers," said senior author P. Murali Doraiswamy, professor of psychiatry and medicine at Duke.

Duke neuroscience research trainee Erika J. Lampert, Doraiswamy and colleagues analyzed data from 257 adults, ages 55 to 89, both cognitively healthy and with varying levels of impairment. The participants were part of the Alzheimer's Disease Neuroimaging Initiative, a national study working to define the progression of Alzheimer's through biomarkers.

The researchers looked at participants' age, gender and family history of the disease, with a positive family history defined as having a parent or sibling with Alzheimer's. This information was compared with cognitive assessments and other biological tests, including APOE genotyping, MRI scans measuring hippocampal volume, and studies of three different pathologic markers (A?42, t-tau, and t-tau/A?42 ratio) found in cerebrospinal fluid.

As expected, the researchers found that a variation in the APOE gene associated with a greater risk and earlier onset of Alzheimer's was overrepresented in participants with a family history of the disease. However, other biological differences were also seen in those with a family history, suggesting that unidentified genetic factors may influence the disease's development before the onset of dementia.

Nearly half of all healthy people with a positive family history would have met the criteria for preclinical Alzheimer's disease based on measurements of their cerebrospinal fluid, but only about 20 percent of those without a family history would have met such criteria.

"We already knew that family history increases one's risk for developing Alzheimer's, but we now are showing that people with a positive family history may also have higher levels of Alzheimer's pathology earlier, which could be a reason why they experience a faster cognitive decline than those without a family history," Lampert said.

The findings may influence the design of future studies developing new diagnostic tests for Alzheimer's, as researchers may choose to exclude those with a positive family history -- a group that has historically volunteered to participate in studies to better understand the disease -- as healthy controls, given that they are more likely to develop Alzheimer's pathology.

"Our study shows the power of a simple one-minute questionnaire about family history to predict silent brain changes," Doraiswamy said. "In the absence of full understanding of all genetic risks for late-onset Alzheimer's, family history information can serve as a risk stratification tool for prevention research and personalizing care." He encouraged those with a known positive family history to seek out clinical trials specific to preventing the disease.

In addition to Lampert and Doraiswamy, study authors include Kingshuk Roy Choudhury, Christopher A. Hostage and Jeffrey R. Petrella.

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The above story is reprinted from materials provided by Duke University Medical Center.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Erika J. Lampert, Kingshuk Roy Choudhury, Christopher A. Hostage, Jeffrey R. Petrella, P. Murali Doraiswamy. Prevalence of Alzheimer?s Pathologic Endophenotypes in Asymptomatic and Mildly Impaired First-Degree Relatives. PLoS ONE, 2013; 8 (4): e60747 DOI: 10.1371/journal.pone.0060747

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/ooEFGQBcYqM/130417185901.htm

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Your 2Dope Review Of KiD CuDi's Indicud | 2dopeboyz

Last week, KiD CuDi surprised his fans with an announcement stating he would be pushing the release of his new album up a week (due to an early leak). And now that Indicud is in stores (and on iTunes) and most die-hard fans already gave it a ?preview? listen, we?d like to ask the dopeboyz/girlz what they think of the latest album from the former G.O.O.D. Music musician. What are your favorite tracks? How does it hold up against his previous efforts? Favorite guest appearance? Let us know it all!

Source: http://www.2dopeboyz.com/2013/04/16/your-2dope-review-of-kid-cudis-indicud/

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Expand2Web 016: Why Content Is King!

Podcast: Play in new window | Download (28.8MB)

Websites with Blogs get 55% more traffic than other websites.

Why? Because websites with blogs get updated more frequently with unique content.

In this session of the Expand2Web Podcast, I talk with copywriter and digital marketer Jennifer Nice, President of Write-Nice. Jennifer shares her story on how she started out as a writer in 3rd grade. She later went on to become a language arts teacher. Then two years ago she sailed around the world with her family, left her teaching job, and started her own business on the web (using the SmallBiz Theme I?m proud to say!).

Jennifer shares some awesome tips for any business owner or internet marketer in this interview.

In This Podcast You?ll Learn About:

Practical tips about content for your website like:

1. Common mistakes businesses make with their websites that costs them rankings and traffic
2. How people read on the web, and how you can use this to make your content more effective
3. How writing for the web is different than other types of writing
4. Why Content Marketing is the best way to market your business now (and what is Content Marketing anyway? Jennifer has a great definition.)
5. What kind of content should a business put on their website? We share some specific examples in the interview
6. The main place website projects break down, and how to get past it!
7. How to hire a copywriter (including a helpful template you can use to save money)
8. Why WordPress is a great way to go for your business website

Resources Mentioned In This Podcast

Listen to the Podcast about Content Marketing

You can listen to the podcast by clicking the play button at the top of this post. Or you can download the MP3 audio file by clicking the download link if you?re like me and you listen to interviews on your iPod/iPhone in the car.

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Source: http://www.expand2web.com/blog/why-content-is-king/

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